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audials 8 - Acyclovir loaded chitosan microspheres31 and Pilocarpine-loaded albumin or gelatin microspheres32 are available. The drug is re­leased in cul-de-sac through diffusion, chemical reaction, and polymer degradation and micro particles are larger than nanoparticles. audials 8 - Microparticulate technology has the advantage of better patient acceptability, since they can be topically administered as an eye drop33. But the manufacture and control of large scale manufacturing of sterile micro particulates is very challenging and expensive. audials 8 - It was an atropine containing gelatin wa­fer and in 1980's numerous systems were developed using various polymora and different drug release principles for controlled drug release. audials 8 -       Solid inserts were introduced into the market 50 years ago. The first solid insert was described in 1948 in British Pharmacopoeia audials 8.       Insoluble inserts are polymeric systems into which the drug is incorporated as a solution or dispersion21 audials 8.